Mesothelioma Lawyer: Fwd: Cascade genetic testing for mismatch repair gene mutations.

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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Apr 6, 2008 at 12:45 PM
Subject: Cascade genetic testing for mismatch repair gene mutations.
To: mesothelioma77@gmail.com

[1]Fam Cancer. 2008 Apr 4;
Mitchell RJ, Ferguson RK, Macdonald A, Dunlop MG, Campbell H, Porteous ME

Mismatch repair gene mutation carriers have a high risk of developing colorectal cancer, and can benefit from appropriate surveillance. A combined population based ascertainment cascade genetic testing approach provides a systematic and potentially effective strategy for identifying such carriers. We have developed a Markov Chain computer model system which simulates various factors influencing cascade genetic testing; including demographics, uptake, genetic epidemiology and family size. This was used to evaluate cascade genetic testing for mismatch repair gene mutations in theory and practice. Simulations focussed on the population of Scotland by way of illustration, and were based on a 20-year programme in which index cases were ascertained from colorectal cancer cases aged

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Source: http://www.hubmed.org/display.cgi?uids=18389387
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