Mesothelioma Lawyer: Fw: Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas.

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From: HubMed - mesothelioma <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Tuesday, March 11, 2008 10:08:52 PM
Subject: Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas.

[1]Mod Pathol. 2008 Mar 7;
Chiosea S, Krasinskas A, Cagle PT, Mitchell KA, Zander DS, Dacic S

Definitive diagnosis of malignant mesothelioma in small specimens can be extremely difficult based on morphology alone. Homozygous deletion of 9p21, the locus harboring the p16 gene, has been reported as the most common genetic alteration in malignant mesotheliomas. Recent studies demonstrated that this alteration may be useful for differentiating benign from malignant mesothelial proliferations in cytology specimens. The aim of this study was to evaluate the diagnostic utility of homozygous deletion of 9p21 assessed by fluorescence in situ hybridization (FISH) in mesothelial proliferations involving serosal surfaces in paraffin-embedded tissue. p16 protein immunoexpression was also explored as a potential diagnostic aid. FISH analysis demonstrated homozygous deletion of the 9p21 locus in 35 of 52 cases (67%) of pleural mesothelioma and in 5 of 20 cases of peritoneal mesothelioma (25%) (P

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Source: http://www.hubmed.org/display.cgi?uids=18327208
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