Monday, August 25, 2008

Fwd: The oxidation of glutathione by cobalt/tungsten carbide contributes to hard metal-induced oxidative stress.



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From: HubMed - asbestos cancer <rssfwd@rssfwd.com>
Date: Thu, Aug 21, 2008 at 9:31 PM
Subject: The oxidation of glutathione by cobalt/tungsten carbide contributes to hard metal-induced oxidative stress.
To: mesothelioma77@gmail.com


[1]Free Radic Res. 2008 Aug; 42(8): 437-745
Fenoglio I, Corazzari I, Francia C, Bodoardo S, Fubini B

The occupational exposure to cobalt/tungsten carbide (Co/WC) dusts causes asthma and interstitial fibrosis. The International Agency for Research on Cancer (IARC) recently classified the mixture Co/WC as probably carcinogenic to humans (group 2A). The mechanism of action of Co/WC involves particle driven generation of Reactive Oxygen Species (ROS) with consequent oxidative damage. The present study evaluates the reactivity of Co/WC dust toward glutathione (GSH) and cysteine (Cys). Co/WC oxidized thiols through a mechanism involving the generation of sulphur-centred radicals. The results are consistent with the oxidation taking place at surface active sites, a part of which is accessible only to Cys S-H groups, but not to GSH ones. Such a reaction, with consequent irreversible depletion of antioxidant defenses of cells, will potentiate the oxidative stress caused by particle and cell generated ROS.



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Source: http://www.hubmed.org/display.cgi?uids=18712631
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