From: HubMed - mesothelioma cancer <rssfwd@rssfwd.com>
Date: Fri, Apr 11, 2008 at 5:56 PM
Subject: Epidermal growth factor receptor gene mutation, amplification and protein expression in malignant pleural mesothelioma.
To: mesothelioma77@gmail.com
[1]J Cancer Res Clin Oncol. 2008 Apr 8;
Okuda K, Sasaki H, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y
Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial malignancies. In lung cancer cases, EGFR gene mutation at the kinase domain and EGFR gene amplification are reported to be predictors of the response to EGFR tyrosine kinase inhibitors. In malignant pleural mesothelioma (MPM), the role of EGFR is less clear. We studied EGFR gene mutation, amplification and protein expression in 25 Japanese patients with MPM. None had previously reported EGFR mutations detected by the TaqMan PCR assay. Using immunohistochemistry, 8/25 (32%) cases were positive for the EGFR protein. The cases of sarcomatous type and desmoplastic type were all negative. Fluorescence in situ hybridization analysis revealed three low polysomy cases and one high polysomy case. The low polysomy cases included one biphasic type and two epithelial types, and the high polysomy case was epithelial type. These four cases expressed EGFR protein. In MPM, EGFR seems to play a role in a limited subset of patients. To identify possible candidates for EGFR tyrosine kinase in inhibitor therapy, the information on the EGFR gene status may be valuable.
___
Source: http://www.hubmed.org/display.cgi?uids=18392851
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc
Health Sites
Relieve Stress Anxiety Tensions
Mesothelioma diagnosis: What You Need To Know
More Links, Links
http://www.lingwellness.com/privatestudentloans.php
http://www.lingwellness.com/mortgagerefinancing.php
http://www.lingwellness.com/realestate.php
http://www.lingwellness.com/msbeachvacationcondos.php
http://www.lingwellness.com/margaterealestate.php
http://www.lingwellness.com/hudapprovedbuilders.php
http://www.lingwellness.com/bankruptcymarketing.php
http://www.lingwellness.com/bankruptcymailinglist.php
http://www.lingwellness.com/enterbankruptcyprotection.php
http://www.lingwellness.com/debtconsolidationuk2.php
http://www.debt2consolidationloan.com/
http://www.debt2consolidationloan.com/
http://www.debt2consolidationloan.com/School_Loan_Consolidation_Beginners_Info.html
http://www.debt2consolidationloan.com/School_Consolidation_Loans_Guide.html
http://www.debt2consolidationloan.com/College_Loan_Consolidation.html
http://www.debt2consolidationloan.com/Student_Loans.html