From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Fri, Mar 28, 2008 at 3:15 PM
Subject: The role of ovarian ablation in the adjuvant therapy of breast cancer.
To: mesothelioma77@gmail.com
[1]Curr Oncol Rep. 2008 Jan; 10(1): 27-37
Tan SH, Wolff AC
Increasing interest has emerged in the role of ovarian function suppression, which has shown equivalence to adjuvant CMF (cyclophosphamide, methotrexate, 5-fluorouracil), whether achieved by surgery or irradiation, in breast cancer patients. Studies have suggested temporary amenorrhea can confer benefit in early breast cancer, giving luteinizing hormone-releasing hormone (LH-RH) agonists an advantage over oophorectomy or radiation. Compared with no therapy, LH-RH agonists reduce risks of recurrence and death among women younger than 50 years of age who have hormone receptor-positive tumors. Trials are assessing the benefits of adding LH-RH agonists to aromatase inhibitors, tamoxifen, or after chemotherapy in women remaining premenopausal, and the necessity for adjuvant chemotherapy with combined ovarian ablation and antiestrogen therapy.
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Source: http://www.hubmed.org/display.cgi?uids=18366958
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