----- Forwarded Message ----
From: HubMed - mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Thursday, February 28, 2008 2:03:44 PM
Subject: Pleural mesothelioma: diagnostic problems and evaluation of prognostic factors.
[1]J Egypt Natl Canc Inst. 2006 Dec; 18(4): 303-10
Ismail HM, A Nouh MA, Abulkheir IL, Abd El-Rahman Ael-R, Tawfik HN
Background: Malignant pleural mesothelioma (MPM) in Egypt is mainly attributed to an environmental origin i.e exposure to asbestos, with a high incidence in women and young adults. Immunohistochemistry and ultrastructural features aid in the diagnosis. The p27Kip1 is a kinase inhibitor protein acting as a cell cycle regulator and a putative tumor suppressor gene playing a critical role in the pathogenesis of several human neoplasms. Aim: A clinicopathologic, immunohistochemical and ultrastructural study of mesothelioma in Egyptian patients, with identification of different prognostic factors. Material and Methods: Sixty-one cases of MPM were collected from the department of pathology at the NCI, Cairo. Cases were stained by monoclonal antibodies against CK5 /6, calretinin, vimentin, CD15, CEA and p27. Results: More than half (57.4%) of the patients were residents in endemic areas; 50.8% were of epithelioid type. CK5 / 6 was positive in 45 (73.8%) cases, 39 (63.9%) cases were positive for vimentin, 49 (80.3%) cases were positive for calretinin. One case showed a focal weak positive reaction to CD15. None of the cases stained for CEA. There was a statistically significant relation between p27 expression and the histopathologic type (p =0.02) between overall survival and age (p = 0.01), histopathologic type (p =0.02) and stage (p =0.006). Conclusion: MPM is an increasing disaster in Egypt which is underestimated and neglected. A panel of immunohistochemical markers should be used for proper evaluation. p27 has proven to be a potential biologic prognostic marker for mesothelioma and more studies as regard its significance are recommended on a larger number. Key Words: Mesothelioma - Asbestos - CK5 / 6 - Calretinin- p27.
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Source: http://www.hubmed.org/display.cgi?uids=18301454
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From: HubMed - mesothelioma diagnosis <rssfwd@rssfwd.com>
To: shell8377@yahoo.com
Sent: Thursday, February 28, 2008 2:03:44 PM
Subject: Pleural mesothelioma: diagnostic problems and evaluation of prognostic factors.
[1]J Egypt Natl Canc Inst. 2006 Dec; 18(4): 303-10
Ismail HM, A Nouh MA, Abulkheir IL, Abd El-Rahman Ael-R, Tawfik HN
Background: Malignant pleural mesothelioma (MPM) in Egypt is mainly attributed to an environmental origin i.e exposure to asbestos, with a high incidence in women and young adults. Immunohistochemistry and ultrastructural features aid in the diagnosis. The p27Kip1 is a kinase inhibitor protein acting as a cell cycle regulator and a putative tumor suppressor gene playing a critical role in the pathogenesis of several human neoplasms. Aim: A clinicopathologic, immunohistochemical and ultrastructural study of mesothelioma in Egyptian patients, with identification of different prognostic factors. Material and Methods: Sixty-one cases of MPM were collected from the department of pathology at the NCI, Cairo. Cases were stained by monoclonal antibodies against CK5 /6, calretinin, vimentin, CD15, CEA and p27. Results: More than half (57.4%) of the patients were residents in endemic areas; 50.8% were of epithelioid type. CK5 / 6 was positive in 45 (73.8%) cases, 39 (63.9%) cases were positive for vimentin, 49 (80.3%) cases were positive for calretinin. One case showed a focal weak positive reaction to CD15. None of the cases stained for CEA. There was a statistically significant relation between p27 expression and the histopathologic type (p =0.02) between overall survival and age (p = 0.01), histopathologic type (p =0.02) and stage (p =0.006). Conclusion: MPM is an increasing disaster in Egypt which is underestimated and neglected. A panel of immunohistochemical markers should be used for proper evaluation. p27 has proven to be a potential biologic prognostic marker for mesothelioma and more studies as regard its significance are recommended on a larger number. Key Words: Mesothelioma - Asbestos - CK5 / 6 - Calretinin- p27.
___
Source: http://www.hubmed.org/display.cgi?uids=18301454
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