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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: P53 Overexpression in Bladder Urothelial Neoplasms: New Aspect of World Health Organization/International Society of Urological Pathology Classification.
To: mesothelioma77@gmail.com
[1]Urol J. 2007; 4(4): 230-233
Kalantari MR, Ahmadnia H
INTRODUCTION: The aim of this study was to investigate the probable differences in P53 expression between papillary urothelial neoplasm of low malignant potential (PUNLMP) and varying grades of transitional cell carcinoma (TCC) of the bladder. MATERIALS AND METHODS: Ten biopsy specimens of the patients with PUNLMP, 20 of the patients with papillary low-grade TCC, 20 of those with invasive high-grade TCC, and 10 of healthy individuals were stained for P53 protein by immunohitochemical methods. Histological grading was performed according to the World Health Organization/International Society of Urological Pathology consensus classification of urothelial neoplasms of the urinary bladder. RESULTS: Nuclear P53 protein in invasive high-grade TCC was slightly more frequent than that in noninvasive low-grade papillary TCC (P = .35). Ten percent of specimens with PUNLMP had nuclear P53 accumulation, while in low-grade and high-grade TCCs, 75% and 85% of the specimens were positive for P53 protein accumulation (P
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Source: http://www.hubmed.org/display.cgi?uids=18270948
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From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Thu, Feb 14, 2008 at 11:06 PM
Subject: P53 Overexpression in Bladder Urothelial Neoplasms: New Aspect of World Health Organization/International Society of Urological Pathology Classification.
To: mesothelioma77@gmail.com
[1]Urol J. 2007; 4(4): 230-233
Kalantari MR, Ahmadnia H
INTRODUCTION: The aim of this study was to investigate the probable differences in P53 expression between papillary urothelial neoplasm of low malignant potential (PUNLMP) and varying grades of transitional cell carcinoma (TCC) of the bladder. MATERIALS AND METHODS: Ten biopsy specimens of the patients with PUNLMP, 20 of the patients with papillary low-grade TCC, 20 of those with invasive high-grade TCC, and 10 of healthy individuals were stained for P53 protein by immunohitochemical methods. Histological grading was performed according to the World Health Organization/International Society of Urological Pathology consensus classification of urothelial neoplasms of the urinary bladder. RESULTS: Nuclear P53 protein in invasive high-grade TCC was slightly more frequent than that in noninvasive low-grade papillary TCC (P = .35). Ten percent of specimens with PUNLMP had nuclear P53 accumulation, while in low-grade and high-grade TCCs, 75% and 85% of the specimens were positive for P53 protein accumulation (P
___
Source: http://www.hubmed.org/display.cgi?uids=18270948
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